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Compound Libraries


Compound Libraries

Prestwick FDA Approved Chemical Library

100% approved drugs (FDA, EMA and other agencies)

Click here for list of compounds

NIH Clinical Collection

The NIH Clinical Collection is a plated array of 727 small molecules that have a history of use in human clinical trials and known safety profiles

Click here for list of compounds

NCI/DTP Libraries

  • Diversity Set: Derived from the almost 140,000 compounds available from the DTP repository
  • Mechanistic Set: Derived from the 37,836 open compounds that have been tested in the NCI human tumor 60 cell line screen
  • Approved Oncology Drugs Set: FDA-approved  compounds in clinical use for oncology

Click here for list of compounds

NCATS Mechanism Interrogation PlatE (MIPE)

This library contains a collection of small molecule chemical probes from the literature, investigational drugs, novel agents entering the clinic, and FDA approved drugs. All of the compounds in this library have a known mechanism of action

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PKIS Kinase Inhibitor Set

Collection of kinase inhibitors covering >30 chemotypes provided by GSK (now housed at SGC-UNC) for screening; all compounds have been published in the scientific literature

Sigma Library of Pharmacologically Active Compounds (LOPAC)

Biologically annotated collection of inhibitors, receptor ligands, pharma-developed tools, and approved drugs, which impact most signaling pathways and cover all major drug target classes

Click here for list of compounds

MicroSource Spectrum Collection

Selected by medicinal chemists and biologists so as to provide a wide range of biological activities and structural diversity, includes approved drugs (50%), diverse natural products (30%), and other bioactive compounds (20%)

Maybridge Diversity Library

Structurally diverse and distinct drug-like compound library designed to identify small molecule lead compounds for HTS drug discovery