Assay and Model Overview

The MSU In Vivo Facility offers an extensive list of models and capabilities to suit your efficacy, and early safety testing needs. As part of a large university with a highly respected pharmacology department, a high ranking veterinary teaching and research hospital, and other state-of-the-art facilities, we are able to offer a wide range of in vivo models. Please contact us for more information or to discuss our additional capabilities.

• Acute and Subchronic Toxicity
   
• Early Target Organ Identification
   
• In Vivo Pharmacokinetic Studies
   
• Cardiovascular
  • Radiotelemetry
  • Myocardial Infarction
  • Heart Failure
  • Ischemia/Reperfusion
  • Electrophysiology
  • Pulmonary Artery Hypertension
     
• Neurologic
  • Locomotor Activity
  • Microdialysis
  • Stereotaxic Neurosurgery/Lesioning
  • Cognition
  • Stroke
     
• Ocular
  • Neovascularization
  • Ocular Endpoints for Toxicology Studies
     
• Pulmonary
  • Asthma/Methacholine
  • Pulmonary Fibrosis
  • Cystic Fibrosis
  • Pulmonary Hypertension
     
• Gastrointestinal
  • Colonic Balloon Distension
  • Transit Time/Gastric Emptying
  • Nerve/Muscle Preparations
  • Spatiotemporal Analysis of Peristalsis/Movement
     
• Renal
  • Blood Flow
  • Ischemia/ Reperfusion
  • Renal Function
     
• Vascular
  • Systemic Hypertension
  • Peripheral Artery Disease
     
• Oncology
  • Solid Xenografts
  • Hematogenous Xenografts
     
• Immunology
  • Immunophenotyping
  • Cytokine/Chemokine Analysis
  • Ex Vivo Immune Function
  • Respiratory Burst/Phagocytosis
  • Immunoglobulin Isotyping
  • Antigen-Specific Antibody Response
  • Cell-Based Assays
  • Pharmacodynamic Assay Development
     
• Imaging
  • Radiography
  • Fluoroscopy
  • Echocardiography
  • CT and Micro CT
  • MRI
  • MRS
  • PET
  • Nuclear Scintigraphy
  • IVIS in vivo bioluminescent and fluorescent imaging
  • VEVO rodent high frequency ultrasound
     
• Rodent Stem Cell Models