The MSU In Vivo Facility works with academic clients to test novel compounds, therapeutics, and devices. We offer a talented and experienced team to assist with the in vivo components of your research, thereby streamlining your project. Our services include testing using established in vivo models, development and refinement of in vivo assays, authoring and managing IACUC approved research protocols, and providing Letters of Support for grant submissions.
The guiding principles for in vivo research are the three Rs, and the MSU In Vivo Facility assists researchers in following this doctrine. Our experts can help you select the most efficient models for your project and identify alternative methods where appropriate. In addition, our experienced scientists are proficient in a variety of techniques, meaning more information from smaller data sets, and a reduced need for training. Ultimately, working with the MSU In Vivo Facility helps to save lives as well as costs.
The MSU In Vivo Facility provides support for the majority of the preclinical stages of drug discovery, from initial target identification and validation through assay development and lead optimization to the selection of a candidate molecule for clinical development. Our skilled scientists are trained in a variety of models to generate and report your data, and our experts can apply years of industry experience to help you select the models best suited to your project.
Novel drugs and devices may need novel methods to test safety, efficacy, or other characteristics, or to satisfy budget or timeline constraints. The experts at the MSU In Vivo Facility routinely develop custom models and evaluations to fit a wide range of research needs.
The MSU In Vivo Facility has a great deal of experience in drafting, amending, and updating AUFs, and in managing the IACUC approval process. Many models are already covered under our existing AUFs or simply require an amendment. Working with the MSU In Vivo Facility saves time and resources in the preparation, review, and approval of these documents.
The MSU In Vivo Facility routinely drafts letters of support for grant proposals from a variety of grant institutions, including the NIH. Our experts may have previous experience in the model or assay being utilized, which lends credibility to your proposal and helps to assure reviewers that you have the necessary resources to meet objectives.
The Vevo® 2100 is a high frequency rodent ultrasound system suitable for mice, rats, other rodents, and small rabbits. It provides superb B-Mode (2D) imaging for anatomical visualization and quantification, color and Power Doppler Modes for blood flow quantification & anatomical identification, M-Mode single line acquisition allowing high-temporal resolution for left ventricular functional analysis, and Pulsed-Wave Doppler Mode (PW) for quantification of blood flow, among other imaging options. It may be used for the cardiovascular system, for renal blood flow, or for visualization of abdominal organs.
Once reserved by an investigator, a member of the MSU In Vivo facility will acquire the requested data. The Vevo® 2100 is occasionally available for hands-on use by other trained personnel. Data is then analyzed on a separate workstation by an experienced member of the MSU In Vivo Facility, trained personnel, or by an external expert.
To use the system, the procedures involved must be included on the investigator’s current approved AUF.