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Resources for Assay Development and High Throughput Screening


cover of assay guidance manual

Assay Guidance Manual

  • Descriptions of assay formats that are compatible with HTS
  • Selection and development of optimal assay reagents
  • Optimizations and troubleshooting for assay protocols with respect to sensitivity, dynamic range, signal intensity and stability
  • Adaptations of assays for automation and scaling to microtiter plate formats
  • Instrumentation
  • Sources of assay artifacts and interferences
  • Statistical validation of assay performance parameters
  • Secondary assays for chemical probe validation and SAR refinement
  • Data standards for reporting the results of screening and SAR assays
  • In vivo assay development and validation